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Assay Detail

CHEMBL678403

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Binding
Binding affinity for porcine Elastase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Pancreatic elastase (CHEMBL2096984)
Type PROTEIN FAMILY
Organism Sus scrofa

Publication

Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.
Peet NP, Burkhart JP, Angelastro MR, Giroux EL, Mehdi S, Bey P, Kolb M, Neises B, Schirlin D.
J Med Chem (1990) 33 : 394 -407
PubMed 2296031 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.60 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL130253 1 7.82
CHEMBL131780 1 7.54
CHEMBL337396 1 7.50
CHEMBL130271 1 7.48
CHEMBL339870 1 7.06
CHEMBL131188 1 6.85
CHEMBL130128 1 6.82
CHEMBL130718 1 6.62
CHEMBL436383 1 6.17
CHEMBL446422 1 5.75
CHEMBL340062 1 5.00
CHEMBL132768 1 4.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL130253 Ki = 15.0 nM 7.82
CHEMBL131780 Ki = 29.0 nM 7.54
CHEMBL337396 Ki = 32.0 nM 7.50
CHEMBL130271 Ki = 33.0 nM 7.48
CHEMBL339870 Ki = 88.0 nM 7.06
CHEMBL131188 Ki = 140.0 nM 6.85
CHEMBL130128 Ki = 150.0 nM 6.82
CHEMBL130718 Ki = 240.0 nM 6.62
CHEMBL436383 Ki = 680.0 nM 6.17
CHEMBL446422 Ki = 1800.0 nM 5.75
CHEMBL340062 Ki = 9900.0 nM 5.00
CHEMBL132768 Ki = 28000.0 nM 4.55