Assay Detail
Binding
CHEMBL678522
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Inhibitory activity against estrone sulfatase enzyme
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivation of a possible transition-state for the reaction catalysed by the enzyme estrone Sulfatase (ES).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122708 | EMATE | — | 1 | 10.19 |
| CHEMBL44459 | — | — | 1 | 7.25 |
| CHEMBL11185 | — | — | 1 | 6.42 |
| CHEMBL26036 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122708 | EMATE | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL44459 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL11185 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL26036 | — | IC50 | = | 1000.0 | nM | 6.00 |