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Assay Detail

CHEMBL678523

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Binding
Inhibitory activity against Estrone Sulfatase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Steryl-sulfatase (CHEMBL3559)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.
Ahmed S, James K, Owen CP.
Bioorg Med Chem Lett (2002) 12 : 2391 -2394
PubMed 12161140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.18 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122708 EMATE 1 6.30
CHEMBL420395 1 5.47
CHEMBL78282 1 5.42
CHEMBL80330 1 5.32
CHEMBL421505 1 5.30
CHEMBL306782 1 5.23
CHEMBL76374 1 4.98
CHEMBL11185 1 4.92
CHEMBL77121 1 4.88
CHEMBL305637 1 4.65
CHEMBL79227 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122708 EMATE IC50 = 500.0 nM 6.30
CHEMBL420395 IC50 = 3400.0 nM 5.47
CHEMBL78282 IC50 = 3800.0 nM 5.42
CHEMBL80330 IC50 = 4800.0 nM 5.32
CHEMBL421505 IC50 = 5000.0 nM 5.30
CHEMBL306782 IC50 = 5900.0 nM 5.23
CHEMBL76374 IC50 = 10500.0 nM 4.98
CHEMBL11185 IC50 = 12000.0 nM 4.92
CHEMBL77121 IC50 = 13200.0 nM 4.88
CHEMBL305637 IC50 = 22400.0 nM 4.65
CHEMBL79227 IC50 = 31600.0 nM 4.50