Assay Detail
Binding
CHEMBL678556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.69 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12703 | — | — | 1 | 9.00 |
| CHEMBL11706 | BMS-248360 | — | 1 | 8.70 |
| CHEMBL11840 | — | — | 1 | 8.40 |
| CHEMBL12106 | — | — | 1 | 8.30 |
| CHEMBL266628 | — | — | 1 | 8.30 |
| CHEMBL275545 | — | — | 1 | 8.15 |
| CHEMBL12233 | — | — | 1 | 8.15 |
| CHEMBL12588 | — | — | 1 | 8.10 |
| CHEMBL12013 | — | — | 1 | 7.89 |
| CHEMBL11528 | — | — | 1 | 7.85 |
| CHEMBL12144 | — | — | 1 | 7.82 |
| CHEMBL275523 | — | — | 1 | 7.80 |
| CHEMBL268706 | — | — | 1 | 7.77 |
| CHEMBL429037 | — | — | 1 | 7.70 |
| CHEMBL12175 | — | — | 1 | 7.70 |
| CHEMBL12590 | — | — | 1 | 7.70 |
| CHEMBL12557 | — | — | 1 | 7.66 |
| CHEMBL12333 | — | — | 1 | 7.40 |
| CHEMBL274154 | — | — | 1 | 7.40 |
| CHEMBL12592 | — | — | 1 | 7.26 |
| CHEMBL12102 | — | — | 1 | 7.26 |
| CHEMBL12779 | — | — | 1 | 6.98 |
| CHEMBL417429 | — | — | 1 | 6.38 |
| CHEMBL12172 | — | — | 1 | 6.34 |
| CHEMBL12348 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12703 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL11706 | BMS-248360 | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL11840 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL12106 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL266628 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL275545 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL12233 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL12588 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL12013 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL11528 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL12144 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL275523 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL268706 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL429037 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL12175 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL12590 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL12557 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL12333 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL274154 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL12592 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL12102 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL12779 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL417429 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL12172 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL12348 | — | Ki | = | 700.0 | nM | 6.16 |