Assay Detail
Binding
CHEMBL678559
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Compound was evaluated for its binding affinity towards human Endothelin A receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.33 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24461 | — | — | 1 | 8.85 |
| CHEMBL11706 | BMS-248360 | — | 1 | 8.72 |
| CHEMBL126755 | — | — | 1 | 7.41 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24461 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL11706 | BMS-248360 | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL126755 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1513 | IRBESARTAN | Ki | > | 0.0001 | nM | - |