Assay Detail
Binding
CHEMBL678663
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In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.62 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2137046 | — | — | 1 | 9.80 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 9.20 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.86 |
| CHEMBL31738 | — | — | 1 | 6.75 |
| CHEMBL31089 | — | — | 1 | 6.72 |
| CHEMBL30996 | — | — | 1 | 6.72 |
| CHEMBL31068 | — | — | 1 | 6.70 |
| CHEMBL34216 | — | — | 1 | 6.20 |
| CHEMBL33889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2137046 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL411 | DIETHYLSTILBESTROL | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL1358 | FULVESTRANT | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL31738 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL31089 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL30996 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL31068 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL34216 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL33889 | — | Ki | > | 1000.0 | nM | - |