Assay Detail
Functional
CHEMBL678786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Follicle-stimulating hormone receptor (CHEMBL2024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.14 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295895 | — | — | 1 | 8.92 |
| CHEMBL45770 | — | — | 1 | 8.77 |
| CHEMBL47953 | — | — | 1 | 8.74 |
| CHEMBL433263 | — | — | 1 | 8.57 |
| CHEMBL300022 | — | — | 1 | 8.52 |
| CHEMBL48030 | — | — | 1 | 8.44 |
| CHEMBL49608 | — | — | 1 | 8.14 |
| CHEMBL48375 | — | — | 1 | 8.05 |
| CHEMBL46216 | — | — | 1 | 8.01 |
| CHEMBL49624 | — | — | 1 | 7.89 |
| CHEMBL47059 | — | — | 1 | 7.85 |
| CHEMBL279759 | — | — | 1 | 7.60 |
| CHEMBL296449 | — | — | 1 | 7.17 |
| CHEMBL47500 | — | — | 1 | 7.00 |
| CHEMBL49308 | — | — | 1 | 6.92 |
| CHEMBL44663 | — | — | 1 | 6.82 |
| CHEMBL45976 | — | — | 1 | 6.40 |
| CHEMBL47838 | — | — | 1 | 6.05 |
| CHEMBL417003 | — | — | 1 | 5.92 |
| CHEMBL49540 | — | — | 1 | 5.80 |
| CHEMBL298686 | — | — | 1 | 5.64 |
| CHEMBL50278 | — | — | 1 | 5.52 |
| CHEMBL47420 | — | — | 1 | 5.48 |
| CHEMBL45782 | — | — | 1 | 5.30 |
| CHEMBL432883 | — | — | 1 | 5.05 |
| CHEMBL44802 | — | — | 1 | - |
| CHEMBL300634 | — | — | 1 | - |
| CHEMBL43789 | — | — | 1 | - |
| CHEMBL294937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295895 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL45770 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL47953 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL433263 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL300022 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL48030 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL49608 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL48375 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL46216 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL49624 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL47059 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL279759 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL296449 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL47500 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL49308 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL44663 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL45976 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL47838 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL417003 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL49540 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL298686 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL50278 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL47420 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL45782 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL432883 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL44802 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL300634 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL43789 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL294937 | — | EC50 | > | 20000.0 | nM | - |