Assay Detail
Functional
CHEMBL678787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Follicle-stimulating hormone receptor (CHEMBL2024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.59 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295895 | — | — | 1 | 8.10 |
| CHEMBL49608 | — | — | 1 | 8.02 |
| CHEMBL433263 | — | — | 1 | 7.51 |
| CHEMBL49624 | — | — | 1 | 7.50 |
| CHEMBL47059 | — | — | 1 | 7.46 |
| CHEMBL48375 | — | — | 2 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295895 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL49608 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL433263 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL49624 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL47059 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL48375 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL48375 | — | EC50 | = | 59.0 | nM | 7.23 |