Assay Detail
Binding
CHEMBL678930
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Binding affinity for dopamine transporter was determined in vitro in rat brain using [3H]WIN-35428 s radioligand
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.13 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084884 | — | — | 1 | 7.70 |
| CHEMBL3084870 | — | — | 1 | 7.67 |
| CHEMBL559215 | — | — | 1 | 7.58 |
| CHEMBL310310 | — | — | 1 | 7.52 |
| CHEMBL543231 | — | — | 1 | 7.47 |
| CHEMBL539821 | — | — | 1 | 7.43 |
| CHEMBL3084608 | — | — | 1 | 7.27 |
| CHEMBL545574 | — | — | 1 | 7.26 |
| CHEMBL539829 | — | — | 1 | 7.21 |
| CHEMBL545342 | — | — | 1 | 7.08 |
| CHEMBL3084607 | — | — | 1 | 7.07 |
| CHEMBL3084621 | — | — | 1 | 7.00 |
| CHEMBL3084609 | — | — | 1 | 6.83 |
| CHEMBL542275 | — | — | 1 | 6.82 |
| CHEMBL3084623 | — | — | 1 | 6.80 |
| CHEMBL542521 | — | — | 1 | 6.72 |
| CHEMBL544177 | — | — | 1 | 6.44 |
| CHEMBL541612 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084884 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3084870 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL559215 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL310310 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL543231 | — | Ki | = | 33.6 | nM | 7.47 |
| CHEMBL539821 | — | Ki | = | 36.8 | nM | 7.43 |
| CHEMBL3084608 | — | Ki | = | 53.3 | nM | 7.27 |
| CHEMBL545574 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL539829 | — | Ki | = | 61.7 | nM | 7.21 |
| CHEMBL545342 | — | Ki | = | 84.2 | nM | 7.08 |
| CHEMBL3084607 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL3084621 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL3084609 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL542275 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL3084623 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL542521 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL544177 | — | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL541612 | — | Ki | = | 399.0 | nM | 6.40 |