Assay Detail
Binding
CHEMBL678931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at Dopamine transporter by displacing [3H]WIN-35428 from rat caudate putamen
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.02 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.92 |
| CHEMBL313179 | — | — | 1 | 7.75 |
| CHEMBL316244 | — | — | 1 | 7.21 |
| CHEMBL433340 | — | — | 1 | 7.08 |
| CHEMBL86830 | — | — | 1 | 6.88 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 6.65 |
| CHEMBL84971 | — | — | 1 | 6.58 |
| CHEMBL314433 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL313179 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL316244 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL433340 | — | Ki | = | 83.2 | nM | 7.08 |
| CHEMBL86830 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL84971 | — | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL314433 | — | Ki | = | 813.0 | nM | 6.09 |