Assay Detail
Binding
CHEMBL678932
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Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.45 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.34 |
| CHEMBL305876 | — | — | 1 | 6.28 |
| CHEMBL72703 | — | — | 1 | 5.75 |
| CHEMBL70690 | — | — | 1 | 5.29 |
| CHEMBL305998 | — | — | 1 | 5.27 |
| CHEMBL72319 | — | — | 1 | 5.21 |
| CHEMBL70336 | — | — | 1 | 5.21 |
| CHEMBL72650 | — | — | 1 | 5.10 |
| CHEMBL421679 | — | — | 1 | 5.04 |
| CHEMBL70265 | — | — | 1 | 5.00 |
| CHEMBL304567 | — | — | 1 | - |
| CHEMBL306714 | — | — | 1 | - |
| CHEMBL72735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL305876 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL72703 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL70690 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL305998 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL72319 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL70336 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL72650 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL421679 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL70265 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL304567 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL306714 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL72735 | — | Ki | > | 10000.0 | nM | - |