Assay Detail
Binding
CHEMBL679106
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Binding affinity for dopamine transporter was determined in rat striatal membrane.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.87 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127365 | — | — | 1 | 7.63 |
| CHEMBL127013 | — | — | 1 | 7.63 |
| CHEMBL338469 | — | — | 1 | 7.38 |
| CHEMBL337929 | — | — | 1 | 7.17 |
| CHEMBL339281 | — | — | 1 | 7.13 |
| CHEMBL340816 | — | — | 1 | 6.89 |
| CHEMBL339712 | — | — | 1 | 6.65 |
| CHEMBL126762 | — | — | 1 | 5.97 |
| CHEMBL127790 | — | — | 1 | 5.38 |
| CHEMBL127180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127365 | — | Ki | = | 23.6 | nM | 7.63 |
| CHEMBL127013 | — | Ki | = | 23.65 | nM | 7.63 |
| CHEMBL338469 | — | Ki | = | 42.05 | nM | 7.38 |
| CHEMBL337929 | — | Ki | = | 67.25 | nM | 7.17 |
| CHEMBL339281 | — | Ki | = | 73.8 | nM | 7.13 |
| CHEMBL340816 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL339712 | — | Ki | = | 221.7 | nM | 6.65 |
| CHEMBL126762 | — | Ki | = | 1069.0 | nM | 5.97 |
| CHEMBL127790 | — | Ki | = | 4183.0 | nM | 5.38 |
| CHEMBL127180 | — | Ki | - | nM | - |