Assay Detail
Binding
CHEMBL679108
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Binding affinity towards dopamine transporter
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42553 | — | — | 1 | 7.00 |
| CHEMBL420084 | — | — | 1 | 7.00 |
| CHEMBL318184 | — | — | 1 | 7.00 |
| CHEMBL328204 | — | — | 1 | 7.00 |
| CHEMBL330651 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42553 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL420084 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL318184 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL328204 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL330651 | — | Ki | = | 100.0 | nM | 7.00 |