Assay Detail
Binding
CHEMBL679110
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Binding affinity towards dopamine transporter (DAT)
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 51 | 7.50 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286991 | — | — | 1 | 9.05 |
| CHEMBL28660 | — | — | 1 | 8.89 |
| CHEMBL417660 | — | — | 1 | 8.68 |
| CHEMBL10914 | — | — | 1 | 8.60 |
| CHEMBL26320 | — | — | 1 | 8.43 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.43 |
| CHEMBL29286 | — | — | 1 | 8.41 |
| CHEMBL421862 | — | — | 1 | 8.39 |
| CHEMBL28821 | — | — | 1 | 8.21 |
| CHEMBL28897 | — | — | 1 | 8.19 |
| CHEMBL28712 | — | — | 1 | 8.14 |
| CHEMBL286949 | — | — | 1 | 8.14 |
| CHEMBL28236 | — | — | 1 | 8.12 |
| CHEMBL285566 | — | — | 1 | 8.00 |
| CHEMBL28414 | — | — | 1 | 7.85 |
| CHEMBL28598 | — | — | 1 | 7.82 |
| CHEMBL29003 | — | — | 1 | 7.75 |
| CHEMBL29040 | — | — | 1 | 7.75 |
| CHEMBL31571 | — | — | 1 | 7.72 |
| CHEMBL27748 | — | — | 1 | 7.66 |
| CHEMBL416198 | — | — | 1 | 7.66 |
| CHEMBL28505 | — | — | 1 | 7.50 |
| CHEMBL28133 | — | — | 1 | 7.50 |
| CHEMBL416022 | — | — | 1 | 7.46 |
| CHEMBL283646 | — | — | 1 | 7.43 |
| CHEMBL29151 | — | — | 1 | 7.43 |
| CHEMBL28947 | — | — | 1 | 7.42 |
| CHEMBL28876 | — | — | 1 | 7.41 |
| CHEMBL283620 | — | — | 1 | 7.40 |
| CHEMBL283662 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286991 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL28660 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL417660 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL10914 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL26320 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL281594 | VANOXERINE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL29286 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL421862 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL28821 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL28897 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL28712 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL286949 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL28236 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL285566 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL28414 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL28598 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL29003 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL29040 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL31571 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL27748 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL416198 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL28505 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL28133 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL416022 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL29151 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL283646 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL28947 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL28876 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL283620 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL283662 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL28935 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL28867 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL29065 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL28726 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL416752 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL28907 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL29000 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL31361 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL282312 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL28191 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL283837 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL417305 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL430537 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL27907 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL28125 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL27626 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL282821 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL28306 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL30257 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL281669 | — | Ki | = | 390.0 | nM | 6.41 |