Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL679122

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]ET-1 from Endothelin A receptor
ChEMBL ↗
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Endothelin-1 receptor (CHEMBL252) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
Wu C, Decker ER, Blok N, Bui H, You TJ, Wang J, Bourgoyne AR, Knowles V, Berens KL, Holland GW, Brock TA, Dixon RA.
J Med Chem (2004) 47 : 1969 -1986
PubMed 15055997 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 9.70 10.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL294291 — — 1 10.70
CHEMBL60058 — — 1 10.70
CHEMBL60367 — — 1 10.52
CHEMBL293830 — — 1 10.52
CHEMBL304460 — — 1 10.52
CHEMBL60149 — — 1 10.40
CHEMBL416324 — — 1 10.40
CHEMBL19950 — — 1 10.40
CHEMBL62159 — — 1 10.30
CHEMBL291592 — — 1 10.30
CHEMBL62112 — — 1 10.22
CHEMBL62019 — — 1 10.22
CHEMBL300577 — — 1 10.15
CHEMBL58359 — — 1 10.10
CHEMBL432521 — — 1 10.10
CHEMBL299921 — — 1 10.10
CHEMBL293398 — — 1 10.05
CHEMBL305602 — — 1 10.00
CHEMBL59819 — — 1 9.96
CHEMBL60276 — — 1 9.85
CHEMBL277595 — — 1 9.82
CHEMBL294563 — — 1 9.68
CHEMBL61425 — — 1 9.62
CHEMBL9194 ATRASENTAN 3.0 1 9.51
CHEMBL300547 — — 1 9.41
CHEMBL61711 — — 1 9.17
CHEMBL59288 — — 1 8.90
CHEMBL293421 — — 1 8.86
CHEMBL282724 SITAXENTAN 4.0 1 8.85
CHEMBL58058 — — 1 8.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL294291 — IC50 = 0.02 nM 10.70
CHEMBL60058 — IC50 = 0.02 nM 10.70
CHEMBL60367 — IC50 = 0.03 nM 10.52
CHEMBL293830 — IC50 = 0.03 nM 10.52
CHEMBL304460 — IC50 = 0.03 nM 10.52
CHEMBL60149 — IC50 = 0.04 nM 10.40
CHEMBL416324 — IC50 = 0.04 nM 10.40
CHEMBL19950 — IC50 = 0.04 nM 10.40
CHEMBL62159 — IC50 = 0.05 nM 10.30
CHEMBL291592 — IC50 = 0.05 nM 10.30
CHEMBL62112 — IC50 = 0.06 nM 10.22
CHEMBL62019 — IC50 = 0.06 nM 10.22
CHEMBL300577 — IC50 = 0.07 nM 10.15
CHEMBL299921 — IC50 = 0.08 nM 10.10
CHEMBL432521 — IC50 = 0.08 nM 10.10
CHEMBL58359 — IC50 = 0.08 nM 10.10
CHEMBL293398 — IC50 = 0.09 nM 10.05
CHEMBL305602 — IC50 = 0.1 nM 10.00
CHEMBL59819 — IC50 = 0.11 nM 9.96
CHEMBL60276 — IC50 = 0.14 nM 9.85
CHEMBL277595 — IC50 = 0.15 nM 9.82
CHEMBL294563 — IC50 = 0.21 nM 9.68
CHEMBL61425 — IC50 = 0.24 nM 9.62
CHEMBL9194 ATRASENTAN IC50 = 0.31 nM 9.51
CHEMBL300547 — IC50 = 0.39 nM 9.41
CHEMBL61711 — IC50 = 0.68 nM 9.17
CHEMBL59288 — IC50 = 1.27 nM 8.90
CHEMBL293421 — IC50 = 1.37 nM 8.86
CHEMBL282724 SITAXENTAN IC50 = 1.4 nM 8.85
CHEMBL58058 — IC50 = 1.47 nM 8.83
CHEMBL303806 — IC50 = 2.62 nM 8.58
CHEMBL304860 — IC50 = 12.36 nM 7.91
CHEMBL314691 BQ-123 IC50 = 22.0 nM 7.66
CHEMBL61780 TEZOSENTAN IC50 = 23.0 nM 7.64
CHEMBL957 BOSENTAN IC50 - nM -