Assay Detail
Binding
CHEMBL679182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]GBR-12935 (1.0 nM) in rat striatal synaptosomes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.45 | 4.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44877 | — | — | 1 | 4.67 |
| CHEMBL21640 | — | — | 1 | 4.44 |
| CHEMBL298285 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44877 | — | Ki | = | 21490.0 | nM | 4.67 |
| CHEMBL21640 | — | Ki | = | 36620.0 | nM | 4.44 |
| CHEMBL298285 | — | Ki | = | 57550.0 | nM | 4.24 |