Assay Detail
Binding
CHEMBL679185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity Sprague-Dawley rats using [3H]WIN-35428 ligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.24 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112787 | — | — | 1 | 7.21 |
| CHEMBL2112788 | — | — | 1 | 6.96 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 6.65 |
| CHEMBL2112783 | — | — | 1 | 6.58 |
| CHEMBL2112760 | — | — | 1 | 6.36 |
| CHEMBL2112784 | — | — | 1 | 6.09 |
| CHEMBL2112791 | — | — | 1 | 5.62 |
| CHEMBL2112789 | — | — | 1 | 5.41 |
| CHEMBL324896 | — | — | 1 | 5.31 |
| CHEMBL110726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112787 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2112788 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL2112783 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL2112760 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL2112784 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL2112791 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL2112789 | — | Ki | = | 3890.0 | nM | 5.41 |
| CHEMBL324896 | — | Ki | = | 4930.0 | nM | 5.31 |
| CHEMBL110726 | — | Ki | = | 112700.0 | nM | - |