Assay Detail
Binding
CHEMBL679322
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Binding affinity for estrogen receptor alpha
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267385 | — | — | 1 | 9.00 |
| CHEMBL281499 | — | — | 1 | 8.37 |
| CHEMBL24950 | — | — | 1 | 7.46 |
| CHEMBL25228 | — | — | 1 | 7.04 |
| CHEMBL432454 | — | — | 1 | 6.76 |
| CHEMBL25580 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267385 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL281499 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL24950 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL25228 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL432454 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL25580 | — | IC50 | = | 366.0 | nM | 6.44 |