Assay Detail
Binding
CHEMBL679325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]17-beta-estradiol from human Estrogen receptor alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 8.70 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.52 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.22 |
| CHEMBL1627354 | — | — | 1 | 8.05 |
| CHEMBL1627351 | — | — | 1 | 7.50 |
| CHEMBL1628199 | — | — | 1 | 7.48 |
| CHEMBL33899 | — | — | 1 | 7.41 |
| CHEMBL1628170 | — | — | 1 | 7.34 |
| CHEMBL1627356 | — | — | 1 | 7.03 |
| CHEMBL1627353 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1627354 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1627351 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1628199 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL33899 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1628170 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1627356 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1627353 | — | IC50 | = | 397.0 | nM | 6.40 |