Assay Detail
Functional
CHEMBL679352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphenyl)-2-phenylethenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.28 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50995 | — | — | 1 | 8.15 |
| CHEMBL357283 | — | — | 1 | 8.05 |
| CHEMBL149791 | — | — | 1 | 7.82 |
| CHEMBL150461 | — | — | 1 | 7.52 |
| CHEMBL357824 | — | — | 1 | 7.30 |
| CHEMBL415864 | — | — | 1 | 6.82 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.30 |
| CHEMBL356693 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50995 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL357283 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL149791 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL150461 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL357824 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL415864 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL356693 | — | IC50 | = | 500.0 | nM | 6.30 |