Assay Detail
Binding
CHEMBL679530
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Compound ability to inhibit the transfer of [3H]- farnesyl from Farnesyltransferase to H-Ras-CVLS, a process that is mediated by FPT
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.93 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333864 | — | — | 1 | 8.89 |
| CHEMBL357148 | — | — | 1 | 8.74 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 8.72 |
| CHEMBL344068 | — | — | 1 | 8.64 |
| CHEMBL358796 | — | — | 1 | 8.60 |
| CHEMBL356519 | — | — | 1 | 8.59 |
| CHEMBL342099 | — | — | 1 | 8.51 |
| CHEMBL69954 | — | — | 1 | 8.30 |
| CHEMBL343845 | — | — | 1 | 8.22 |
| CHEMBL144337 | — | — | 1 | 7.78 |
| CHEMBL142724 | — | — | 1 | 7.48 |
| CHEMBL144031 | — | — | 1 | 7.31 |
| CHEMBL358047 | — | — | 1 | 7.21 |
| CHEMBL144029 | — | — | 1 | 7.11 |
| CHEMBL356935 | — | — | 1 | 7.07 |
| CHEMBL41934 | — | — | 1 | 7.05 |
| CHEMBL289404 | — | — | 1 | 6.60 |
| CHEMBL67405 | — | — | 1 | - |
| CHEMBL343197 | — | — | 1 | - |
| CHEMBL144597 | — | — | 1 | - |
| CHEMBL342349 | — | — | 1 | - |
| CHEMBL358957 | — | — | 1 | - |
| CHEMBL358120 | — | — | 1 | - |
| CHEMBL144202 | — | — | 1 | - |
| CHEMBL356500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333864 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL357148 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL344068 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL358796 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL356519 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL342099 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL69954 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL343845 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL144337 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL142724 | — | IC50 | = | 33.1 | nM | 7.48 |
| CHEMBL144031 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL358047 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL144029 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL356935 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL41934 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL289404 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL67405 | — | IC50 | > | 94.0 | nM | - |
| CHEMBL343197 | — | IC50 | > | 88.0 | nM | - |
| CHEMBL144597 | — | IC50 | > | 280.0 | nM | - |
| CHEMBL342349 | — | IC50 | > | 95.0 | nM | - |
| CHEMBL358957 | — | IC50 | < | 3.8 | nM | - |
| CHEMBL358120 | — | IC50 | > | 99.0 | nM | - |
| CHEMBL144202 | — | IC50 | > | 94.0 | nM | - |
| CHEMBL356500 | — | IC50 | > | 110.0 | nM | - |