Compound Detail
CHEMBL357148
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O=C(Cc1cc[n+]([O-])cc1)N1CCN([C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c32)CC1
Basic Information
| ChEMBL ID | CHEMBL357148 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RKNQPYFCXGJISA-RUZDIDTESA-N |
1
Targets
2
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
606.8
MW (Da)
4.47
ALogP
4
HBA
0
HBD
63.4
PSA (Ų)
0.33
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.74 | 8.37 | 1.8 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 36400.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 5400.0 | ng.hr.mL-1 | Macaca fascicularis |
| Cmax | 24.6 | ug | Mus musculus |
| Cmax | 1400.0 | nM | Macaca fascicularis |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 1.8 | nM | 8.74 | Compound ability to inhibit the transfer of [3H]- farnesyl from Farnesyltransfer... | 9822558 |
| Protein farnesyltransferase | IC50 | = | 10.0 | nM | 8.0 | Inhibiting the farnesylation of H-ras proteins in COS-7 monkey cells transiently... | 9822558 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9822558 | 10.1021/jm980462b | Mus musculus | 4 |
| 9822558 | 10.1021/jm980462b | Protein farnesyltransferase | 2 |
| 9822558 | 10.1021/jm980462b | Cynomolgus monkey | 2 |
| 9822558 | 10.1021/jm980462b | NIH-H | 1 |
Data from ChEMBL 36 via Core Engine