Assay Detail
Binding
CHEMBL679539
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Tested for the inhibitory activity against Estrone Sulfatase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.59 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122708 | EMATE | — | 1 | 10.19 |
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | 8.10 |
| CHEMBL44459 | — | — | 1 | 7.25 |
| CHEMBL11185 | — | — | 1 | 6.42 |
| CHEMBL26036 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122708 | EMATE | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL286738 | IROSUSTAT | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL44459 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL11185 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL26036 | — | IC50 | = | 1000.0 | nM | 6.00 |