Assay Detail
Binding
CHEMBL679541
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Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | MCF7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A novel type of nonsteroidal estrone sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.10 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122708 | EMATE | — | 1 | 7.10 |
| CHEMBL231602 | MHL CYCLOHEXYLTHIOSEMICARBAZONE | — | 1 | 6.34 |
| CHEMBL26541 | — | — | 1 | 5.85 |
| CHEMBL27369 | — | — | 1 | 5.75 |
| CHEMBL11185 | — | — | 1 | 5.58 |
| CHEMBL26969 | — | — | 1 | 5.50 |
| CHEMBL25760 | — | — | 1 | 5.40 |
| CHEMBL26414 | — | — | 1 | 5.32 |
| CHEMBL284412 | — | — | 1 | 5.22 |
| CHEMBL285331 | — | — | 1 | 5.22 |
| CHEMBL25794 | — | — | 1 | 5.16 |
| CHEMBL26041 | — | — | 1 | 5.10 |
| CHEMBL286960 | — | — | 1 | 5.10 |
| CHEMBL27198 | — | — | 1 | 5.05 |
| CHEMBL27864 | — | — | 1 | 4.96 |
| CHEMBL26970 | — | — | 1 | 4.92 |
| CHEMBL287229 | — | — | 1 | 4.89 |
| CHEMBL27368 | — | — | 1 | 4.82 |
| CHEMBL27657 | — | — | 1 | 4.80 |
| CHEMBL286712 | — | — | 1 | 4.75 |
| CHEMBL27197 | — | — | 1 | 4.72 |
| CHEMBL27721 | — | — | 1 | 4.70 |
| CHEMBL27057 | — | — | 1 | 4.66 |
| CHEMBL26958 | — | — | 1 | 4.64 |
| CHEMBL286518 | — | — | 1 | 4.62 |
| CHEMBL26647 | — | — | 1 | 4.60 |
| CHEMBL27775 | — | — | 1 | 4.54 |
| CHEMBL422576 | — | — | 1 | 4.39 |
| CHEMBL285011 | — | — | 1 | 4.30 |
| CHEMBL26480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122708 | EMATE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL231602 | MHL CYCLOHEXYLTHIOSEMICARBAZONE | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL26541 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL27369 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL11185 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL26969 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL25760 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL26414 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL284412 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL285331 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL25794 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL26041 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL286960 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL27198 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL27864 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL26970 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL287229 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL27368 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL27657 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL286712 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL27197 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL27721 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL27057 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL26958 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL286518 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL26647 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL27775 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL422576 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL285011 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL26480 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26959 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283933 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL25967 | — | IC50 | > | 100000.0 | nM | - |