Assay Detail
Binding
CHEMBL679567
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In vitro inhibition of [35S]TBPS binding to GABA-A receptor of rat whole brain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.11 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268249 | — | — | 1 | 5.57 |
| CHEMBL13253 | — | — | 1 | 5.40 |
| CHEMBL12944 | — | — | 1 | 5.38 |
| CHEMBL12861 | — | — | 1 | 5.21 |
| CHEMBL13667 | — | — | 1 | 5.16 |
| CHEMBL276208 | — | — | 1 | 5.01 |
| CHEMBL13080 | — | — | 1 | 4.93 |
| CHEMBL13025 | — | — | 1 | 4.83 |
| CHEMBL13254 | ORG-24447 | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268249 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL13253 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL12944 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL12861 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL13667 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL276208 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL13080 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL13025 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL13254 | ORG-24447 | IC50 | = | 29300.0 | nM | 4.53 |