Assay Detail
Binding
CHEMBL679575
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Inhibitory activity against Leishmania major Farnesyl-diphosphatesynthase (FPP synthase)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.12 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54714 | — | — | 1 | 6.62 |
| CHEMBL55959 | — | — | 1 | 5.89 |
| CHEMBL300532 | — | — | 1 | 5.85 |
| CHEMBL56078 | — | — | 1 | - |
| CHEMBL52620 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54714 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL55959 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL300532 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL56078 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52620 | — | IC50 | > | 100000.0 | nM | - |