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Assay Detail

CHEMBL679598

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Binding
Inhibitory activity against Ras Farnesyl Protein transferase from bovine brain
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Protein farnesyltransferase (CHEMBL2095178)
Type PROTEIN COMPLEX
Organism Bos taurus

Publication

Pseudopeptide inhibitors of Ras farnesyl-protein transferase.
Graham SL, deSolms SJ, Giuliani EA, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Breslin MJ, Deana AA.
J Med Chem (1994) 37 : 725 -732
PubMed 8145221 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.07 8.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL164529 1 8.32
CHEMBL2371387 1 8.15
CHEMBL2371378 1 7.75
CHEMBL2052018 1 7.70
CHEMBL2371366 1 7.57
CHEMBL2371375 1 7.54
CHEMBL2371371 1 7.38
CHEMBL2371383 1 7.30
CHEMBL166022 1 6.85
CHEMBL162328 1 6.82
CHEMBL55423 1 6.78
CHEMBL2371372 1 6.48
CHEMBL348915 1 6.40
CHEMBL2371368 1 6.26
CHEMBL2371370 1 4.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL164529 IC50 = 4.8 nM 8.32
CHEMBL2371387 IC50 = 7.0 nM 8.15
CHEMBL2371378 IC50 = 18.0 nM 7.75
CHEMBL2052018 IC50 = 20.0 nM 7.70
CHEMBL2371366 IC50 = 27.0 nM 7.57
CHEMBL2371375 IC50 = 29.0 nM 7.54
CHEMBL2371371 IC50 = 42.0 nM 7.38
CHEMBL2371383 IC50 = 50.0 nM 7.30
CHEMBL166022 IC50 = 140.0 nM 6.85
CHEMBL162328 IC50 = 150.0 nM 6.82
CHEMBL55423 IC50 = 165.0 nM 6.78
CHEMBL2371372 IC50 = 330.0 nM 6.48
CHEMBL348915 IC50 = 400.0 nM 6.40
CHEMBL2371368 IC50 = 550.0 nM 6.26
CHEMBL2371370 IC50 = 16700.0 nM 4.78