Assay Detail
Binding
CHEMBL679645
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In vitro binding affinity against Gamma-aminobutyric acid type B receptor in rat brain synaptic membranes at pH 7.4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.52 |
| CHEMBL349005 | — | — | 1 | 5.11 |
| CHEMBL351355 | — | — | 1 | 4.85 |
| CHEMBL1788265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL349005 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL351355 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1788265 | — | IC50 | > | 100000.0 | nM | - |