Assay Detail
Binding
CHEMBL679655
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Inhibition of [3H]CGP-27492 binding to Gamma-aminobutyric acid type B receptor of rat cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.84 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112710 | — | — | 1 | 10.80 |
| CHEMBL112203 | — | — | 1 | 8.27 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.77 |
| CHEMBL301742 | ARBACLOFEN | 3.0 | 1 | 7.50 |
| CHEMBL701 | BACLOFEN | 4.0 | 1 | 6.97 |
| CHEMBL325921 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112710 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL112203 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL301742 | ARBACLOFEN | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL701 | BACLOFEN | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL325921 | — | IC50 | = | 1979.0 | nM | 5.70 |