Assay Detail
Binding
CHEMBL679672
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Inhibitory activity of compound against Epidermal growth factor receptor autophosphorylation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.06 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144791 | — | — | 1 | 5.85 |
| CHEMBL67535 | — | — | 1 | 5.48 |
| CHEMBL144770 | — | — | 1 | 5.41 |
| CHEMBL144589 | — | — | 1 | 5.37 |
| CHEMBL296407 | — | — | 1 | 5.35 |
| CHEMBL56393 | — | — | 1 | 5.30 |
| CHEMBL343887 | — | — | 1 | 5.00 |
| CHEMBL144159 | — | — | 1 | 4.99 |
| CHEMBL144760 | — | — | 1 | 4.96 |
| CHEMBL356324 | — | — | 1 | 4.92 |
| CHEMBL144778 | — | — | 1 | 4.87 |
| CHEMBL145266 | — | — | 1 | 4.72 |
| CHEMBL144842 | — | — | 1 | 4.70 |
| CHEMBL358746 | — | — | 1 | 4.68 |
| CHEMBL279138 | — | — | 1 | 4.68 |
| CHEMBL358494 | — | — | 1 | 4.60 |
| CHEMBL145209 | — | — | 1 | - |
| CHEMBL342792 | — | — | 1 | - |
| CHEMBL143108 | — | — | 1 | - |
| CHEMBL357161 | — | — | 1 | - |
| CHEMBL144908 | — | — | 1 | - |
| CHEMBL357400 | — | — | 1 | - |
| CHEMBL144402 | — | — | 1 | - |
| CHEMBL147880 | — | — | 1 | - |
| CHEMBL424302 | — | — | 1 | - |
| CHEMBL144632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144791 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL67535 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL144770 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL144589 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL296407 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL56393 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL343887 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL144159 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL144760 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL356324 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL144778 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL145266 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL144842 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL358746 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL279138 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL358494 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL145209 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL342792 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL143108 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL357161 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144908 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL357400 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL144402 | — | IC50 | > | 167000.0 | nM | - |
| CHEMBL147880 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL424302 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144632 | — | IC50 | > | 100000.0 | nM | - |