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Assay Detail

CHEMBL679754

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Binding
Inhibitory activity measured against alpha-galactosidase of coffee bean by colorimetric assay using the D-glucose oxidase-peroxidase method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Coffea arabica
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Alpha-galactosidase A (CHEMBL2524)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
Asano N, Nishida M, Kato A, Kizu H, Matsui K, Shimada Y, Itoh T, Baba M, Watson AA, Nash RJ, Lilley PM, Watkin DJ, Fleet GW.
J Med Chem (1998) 41 : 2565 -2571
PubMed 9651160 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.65 5.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL87169 1 5.19
CHEMBL1169500 1 4.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL87169 IC50 = 6400.0 nM 5.19
CHEMBL1169500 IC50 = 80000.0 nM 4.10