Assay Detail
Binding
CHEMBL679767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Percent displacement of [3H]GABA at Gamma-aminobutyric acid receptor in rat brain membranes at 0.01 uM
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gamma-aminobutyric acid receptor subunit gamma-1 (CHEMBL296) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(+/-)-trans-2-(Aminomethyl)cyclobutanecarboxylic acid hydrochloride: a rigid analogue of gamma-aminobutyric acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.42 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417990 | BICUCULLINE | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417990 | BICUCULLINE | IC50 | = | 3800.0 | nM | 5.42 |