Assay Detail
Binding
CHEMBL679830
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Binding affinity to CHO cells stably expressing human Endothelin A receptor.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.69 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359273 | — | — | 1 | 9.05 |
| CHEMBL24461 | — | — | 1 | 8.85 |
| CHEMBL149232 | — | — | 1 | 8.64 |
| CHEMBL345951 | — | — | 1 | 8.48 |
| CHEMBL357077 | — | — | 1 | 8.40 |
| CHEMBL150260 | — | — | 1 | 8.25 |
| CHEMBL147340 | — | — | 1 | 8.21 |
| CHEMBL148719 | — | — | 1 | 8.17 |
| CHEMBL149010 | — | — | 1 | 7.72 |
| CHEMBL346862 | — | — | 1 | 7.60 |
| CHEMBL147238 | — | — | 1 | 7.43 |
| CHEMBL149763 | — | — | 1 | 7.42 |
| CHEMBL148855 | — | — | 1 | 7.36 |
| CHEMBL147365 | — | — | 1 | 6.66 |
| CHEMBL149592 | — | — | 1 | 6.57 |
| CHEMBL149340 | — | — | 1 | 6.52 |
| CHEMBL149778 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359273 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL24461 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL149232 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL345951 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL357077 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL150260 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL147340 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL148719 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL149010 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL346862 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL147238 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL149763 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL148855 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL147365 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL149592 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL149340 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL149778 | — | Ki | = | 3800.0 | nM | 5.42 |