Assay Detail
Binding
CHEMBL679844
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In vitro inhibition of Endothelin-converting enzyme 1.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.32 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317472 | — | — | 1 | 8.02 |
| CHEMBL102527 | — | — | 1 | 8.01 |
| CHEMBL292748 | — | — | 1 | 7.96 |
| CHEMBL319463 | — | — | 1 | 7.64 |
| CHEMBL421021 | — | — | 1 | 7.62 |
| CHEMBL102815 | — | — | 1 | 7.57 |
| CHEMBL103327 | — | — | 1 | 7.52 |
| CHEMBL419170 | — | — | 1 | 7.41 |
| CHEMBL421586 | — | — | 1 | 7.39 |
| CHEMBL105054 | — | — | 1 | 7.37 |
| CHEMBL320400 | — | — | 1 | 7.31 |
| CHEMBL103378 | — | — | 1 | 7.26 |
| CHEMBL104617 | — | — | 1 | 7.25 |
| CHEMBL103966 | — | — | 1 | 7.19 |
| CHEMBL64081 | — | — | 1 | 7.11 |
| CHEMBL104814 | — | — | 1 | 7.11 |
| CHEMBL102795 | — | — | 1 | 7.09 |
| CHEMBL320471 | — | — | 1 | 7.01 |
| CHEMBL319708 | — | — | 1 | 6.92 |
| CHEMBL419725 | — | — | 1 | 6.89 |
| CHEMBL441817 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317472 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL102527 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL292748 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL319463 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL421021 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL102815 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL103327 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL419170 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL421586 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL105054 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL320400 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL103378 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL104617 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL103966 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL64081 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL104814 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL102795 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL320471 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL319708 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL419725 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL441817 | — | IC50 | = | 700.0 | nM | 6.16 |