Assay Detail
Binding
CHEMBL679845
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Inhibition of Endothelin-converting enzyme 1 (ECE)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146936 | — | — | 1 | 7.66 |
| CHEMBL43370 | — | — | 1 | 7.10 |
| CHEMBL287358 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146936 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL43370 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL287358 | — | IC50 | = | 620.0 | nM | 6.21 |