Assay Detail
Binding
CHEMBL679847
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Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.97 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147847 | — | — | 1 | 8.10 |
| CHEMBL37052 | — | — | 1 | 7.89 |
| CHEMBL39828 | — | — | 1 | 7.85 |
| CHEMBL285619 | — | — | 1 | 7.77 |
| CHEMBL39887 | — | — | 1 | 7.60 |
| CHEMBL40168 | — | — | 1 | 7.55 |
| CHEMBL39777 | — | — | 1 | 7.55 |
| CHEMBL39714 | — | — | 1 | 7.48 |
| CHEMBL290868 | — | — | 1 | 7.47 |
| CHEMBL416234 | — | — | 1 | 7.37 |
| CHEMBL289150 | — | — | 1 | 7.29 |
| CHEMBL37078 | — | — | 1 | 7.28 |
| CHEMBL37542 | — | — | 1 | 7.25 |
| CHEMBL290304 | — | — | 1 | 7.12 |
| CHEMBL446393 | — | — | 1 | 7.09 |
| CHEMBL289638 | — | — | 1 | 6.96 |
| CHEMBL36382 | — | — | 1 | 6.96 |
| CHEMBL417507 | — | — | 1 | 6.96 |
| CHEMBL35995 | — | — | 1 | 6.96 |
| CHEMBL290256 | — | — | 1 | 6.92 |
| CHEMBL36809 | — | — | 1 | 6.89 |
| CHEMBL287971 | — | — | 1 | 6.85 |
| CHEMBL290332 | — | — | 1 | 6.82 |
| CHEMBL40028 | — | — | 1 | 6.82 |
| CHEMBL290287 | — | — | 1 | 6.80 |
| CHEMBL39812 | — | — | 1 | 6.77 |
| CHEMBL36753 | — | — | 1 | 6.64 |
| CHEMBL39997 | — | — | 1 | 6.64 |
| CHEMBL448098 | — | — | 1 | 6.62 |
| CHEMBL37861 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147847 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL37052 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL39828 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL285619 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL39887 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL40168 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL39777 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL39714 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL290868 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL416234 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL289150 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL37078 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL37542 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL290304 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL446393 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL36382 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL417507 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL289638 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL35995 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL290256 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL36809 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL287971 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL290332 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL40028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL290287 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL39812 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL39997 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL36753 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL448098 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL37861 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL37456 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL434208 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL290698 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL288837 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL39384 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL40161 | — | IC50 | = | 4300.0 | nM | 5.37 |