Assay Detail
Functional
CHEMBL679886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency in cellular transactivation assay utilizing HEK293 cells stably co-transfected with human estrogen receptor alpha and the alkaline phosphatase reporter gene.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.02 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92660 | — | — | 1 | 9.00 |
| CHEMBL327320 | — | — | 1 | 8.77 |
| CHEMBL329902 | — | — | 1 | 8.64 |
| CHEMBL328716 | — | — | 1 | 8.60 |
| CHEMBL94116 | — | — | 1 | 8.47 |
| CHEMBL94225 | — | — | 1 | 8.46 |
| CHEMBL91807 | — | — | 1 | 8.44 |
| CHEMBL92635 | — | — | 1 | 8.40 |
| CHEMBL92027 | — | — | 1 | 8.33 |
| CHEMBL71584 | — | — | 1 | 8.30 |
| CHEMBL93705 | — | — | 1 | 8.27 |
| CHEMBL93793 | — | — | 1 | 8.26 |
| CHEMBL94030 | — | — | 1 | 8.21 |
| CHEMBL329849 | — | — | 1 | 8.03 |
| CHEMBL539927 | — | — | 1 | 8.02 |
| CHEMBL90072 | — | — | 1 | 7.83 |
| CHEMBL327471 | — | — | 1 | 7.65 |
| CHEMBL441457 | — | — | 1 | 7.59 |
| CHEMBL420623 | — | — | 1 | 7.21 |
| CHEMBL93546 | — | — | 1 | 7.03 |
| CHEMBL92720 | — | — | 1 | 6.56 |
| CHEMBL94170 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92660 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL327320 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL329902 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL328716 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL94116 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL94225 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL91807 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL92635 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL92027 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL71584 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL93705 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL93793 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL94030 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL329849 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL539927 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL90072 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL327471 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL441457 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL420623 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL93546 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL92720 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL94170 | — | IC50 | = | 341.9 | nM | 6.47 |