Assay Detail
Binding
CHEMBL679890
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In vitro binding affinity for Estrogen receptor alpha in HEK293 cells
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.64 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304552 | — | — | 1 | 9.10 |
| CHEMBL418327 | — | — | 1 | 8.29 |
| CHEMBL539927 | — | — | 2 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL418327 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL539927 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL539927 | — | IC50 | = | 353.0 | nM | 6.45 |