Assay Detail
Binding
CHEMBL679891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor alpha expressed in 293T cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.51 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92748 | — | — | 1 | 9.30 |
| CHEMBL94280 | — | — | 1 | 8.33 |
| CHEMBL420244 | — | — | 1 | 8.28 |
| CHEMBL93230 | — | — | 1 | 8.25 |
| CHEMBL93586 | — | — | 1 | 8.23 |
| CHEMBL315866 | — | — | 1 | 8.17 |
| CHEMBL93391 | — | — | 1 | 8.10 |
| CHEMBL92900 | — | — | 1 | 8.04 |
| CHEMBL316080 | — | — | 1 | 7.94 |
| CHEMBL93826 | — | — | 1 | 7.70 |
| CHEMBL330307 | — | — | 1 | 7.61 |
| CHEMBL93792 | — | — | 1 | 7.55 |
| CHEMBL89994 | — | — | 1 | 7.54 |
| CHEMBL412907 | — | — | 1 | 7.53 |
| CHEMBL91740 | — | — | 1 | 7.53 |
| CHEMBL91052 | — | — | 1 | 7.51 |
| CHEMBL90008 | — | — | 1 | 7.37 |
| CHEMBL94080 | — | — | 1 | 7.35 |
| CHEMBL328675 | — | — | 1 | 7.30 |
| CHEMBL89995 | — | — | 1 | 7.28 |
| CHEMBL93326 | — | — | 1 | 7.27 |
| CHEMBL328475 | — | — | 1 | 6.95 |
| CHEMBL421368 | — | — | 1 | 6.92 |
| CHEMBL93266 | — | — | 1 | 6.91 |
| CHEMBL93207 | — | — | 1 | 6.80 |
| CHEMBL313849 | — | — | 1 | 6.78 |
| CHEMBL329630 | — | — | 1 | 6.63 |
| CHEMBL91452 | — | — | 1 | 6.42 |
| CHEMBL316292 | — | — | 1 | 6.25 |
| CHEMBL330029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92748 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL94280 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL420244 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL93230 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL93586 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL315866 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL93391 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL92900 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL316080 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL93826 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL330307 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL93792 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL89994 | — | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL412907 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL91740 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL91052 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL90008 | — | IC50 | = | 42.7 | nM | 7.37 |
| CHEMBL94080 | — | IC50 | = | 44.3 | nM | 7.35 |
| CHEMBL328675 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL89995 | — | IC50 | = | 53.1 | nM | 7.28 |
| CHEMBL93326 | — | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL328475 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL421368 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL93266 | — | IC50 | = | 122.7 | nM | 6.91 |
| CHEMBL93207 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL313849 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL329630 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL91452 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL316292 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL330029 | — | IC50 | > | 3200.0 | nM | - |