Assay Detail
Binding
CHEMBL679893
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Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298398 | ANTHRAFLAVICACID | — | 1 | 5.96 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.89 |
| CHEMBL289277 | EMODIN | — | 1 | 5.57 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 5.20 |
| CHEMBL464360 | EMODIN 8-O-BETA-D-GLUCOPYRANOSIDE | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298398 | ANTHRAFLAVICACID | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL44 | GENISTEIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL289277 | EMODIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL464360 | EMODIN 8-O-BETA-D-GLUCOPYRANOSIDE | IC50 | = | 20000.0 | nM | 4.70 |