Assay Detail
Binding
CHEMBL679936
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Binding affinity for dopamine transporter (DAT) labeled with [125 I]RTI-55
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.69 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | 2.0 | 1 | 8.77 |
| CHEMBL542500 | — | — | 1 | 8.77 |
| CHEMBL541605 | — | — | 1 | 8.44 |
| CHEMBL543449 | — | — | 1 | 8.03 |
| CHEMBL543688 | — | — | 1 | 7.94 |
| CHEMBL541602 | — | — | 1 | 7.50 |
| CHEMBL545559 | — | — | 1 | 6.10 |
| CHEMBL554033 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL542500 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL541605 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL543449 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL543688 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL541602 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL545559 | — | Ki | = | 788.0 | nM | 6.10 |
| CHEMBL554033 | — | Ki | = | 1133.0 | nM | 5.95 |