Assay Detail
Functional
CHEMBL679947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphorylation of phospholipase C gamma1 by Epidermal growth factor receptor, from human A431 carcinoma cell vesicles
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.19 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53426 | — | — | 1 | 9.60 |
| CHEMBL299622 | — | — | 1 | 9.12 |
| CHEMBL294475 | — | — | 1 | 9.09 |
| CHEMBL53777 | — | — | 1 | 9.02 |
| CHEMBL53831 | — | — | 1 | 8.82 |
| CHEMBL299881 | — | — | 1 | 8.64 |
| CHEMBL51228 | — | — | 1 | 8.64 |
| CHEMBL417420 | — | — | 1 | 8.54 |
| CHEMBL416307 | — | — | 1 | 8.52 |
| CHEMBL51854 | — | — | 1 | 8.42 |
| CHEMBL52829 | — | — | 1 | 8.40 |
| CHEMBL52591 | — | — | 1 | 8.37 |
| CHEMBL53310 | — | — | 1 | 7.89 |
| CHEMBL298931 | — | — | 1 | 7.77 |
| CHEMBL54067 | — | — | 1 | 7.46 |
| CHEMBL53311 | — | — | 1 | 7.09 |
| CHEMBL52823 | — | — | 1 | 6.42 |
| CHEMBL50027 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53426 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL299622 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL294475 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL53777 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL53831 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL299881 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL51228 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL417420 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL416307 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL51854 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL52829 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL52591 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL53310 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL298931 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL54067 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL53311 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL52823 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL50027 | — | IC50 | = | 2550.0 | nM | 5.59 |