Assay Detail
Binding
CHEMBL679948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-stimulated autophosphorylation of EGFR in A431 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.28 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434827 | — | — | 1 | 7.68 |
| CHEMBL334801 | — | — | 1 | 7.24 |
| CHEMBL345109 | — | — | 1 | 7.23 |
| CHEMBL140561 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434827 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL334801 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL345109 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL140561 | — | IC50 | = | 108.0 | nM | 6.97 |