Assay Detail
Binding
CHEMBL679966
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Dissociation constant when binding to FK506 binding protein (FKBP).
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 4.11 | 4.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72683 | — | — | 1 | 4.22 |
| CHEMBL14189 | 2-PHENYLIMIDAZOLE | — | 1 | 4.00 |
| CHEMBL275066 | — | — | 1 | - |
| CHEMBL83103 | — | — | 1 | - |
| CHEMBL14145 | — | — | 1 | - |
| CHEMBL12626 | — | — | 1 | - |
| CHEMBL313965 | — | — | 1 | - |
| CHEMBL313919 | — | — | 1 | - |
| CHEMBL38876 | — | — | 1 | - |
| CHEMBL315348 | — | — | 1 | - |
| CHEMBL313244 | 4-METHYLESCULETIN | — | 1 | - |
| CHEMBL80094 | — | — | 1 | - |
| CHEMBL81948 | — | — | 1 | - |
| CHEMBL84459 | — | — | 1 | - |
| CHEMBL83148 | PHENYL(PHENYLSULFONYL)AMINE | — | 1 | - |
| CHEMBL85443 | — | — | 1 | - |
| CHEMBL316415 | — | — | 1 | - |
| CHEMBL84047 | — | — | 1 | - |
| CHEMBL39261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72683 | — | Kd | = | 60000.0 | nM | 4.22 |
| CHEMBL14189 | 2-PHENYLIMIDAZOLE | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL275066 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL83103 | — | Kd | = | 410000.0 | nM | - |
| CHEMBL14145 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL12626 | — | Kd | = | 760000.0 | nM | - |
| CHEMBL313965 | — | Kd | = | 500000.0 | nM | - |
| CHEMBL313919 | — | Kd | = | 190000.0 | nM | - |
| CHEMBL38876 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL315348 | — | Kd | = | 130000.0 | nM | - |
| CHEMBL313244 | 4-METHYLESCULETIN | Kd | = | 1500000.0 | nM | - |
| CHEMBL80094 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL81948 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL84459 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL83148 | PHENYL(PHENYLSULFONYL)AMINE | Kd | = | 1000000.0 | nM | - |
| CHEMBL85443 | — | Kd | = | 4000000.0 | nM | - |
| CHEMBL316415 | — | Kd | > | 10000000.0 | nM | - |
| CHEMBL84047 | — | Kd | = | 410000.0 | nM | - |
| CHEMBL39261 | — | Kd | > | 10000000.0 | nM | - |