Compound Detail
CHEMBL14189
2-PHENYLIMIDAZOLE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL14189 |
| Name | 2-PHENYLIMIDAZOLE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZCUJYXPAKHMBAZ-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
144.2
MW (Da)
2.08
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.65
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 4.0
Ki 1 meas. best 5.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nischarin CHEMBL3923 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Serine/threonine-protein kinase mTOR CHEMBL2842 | Kd | 4.0 | 4.0 | 100000.0 | 1 |
| Adenosine kinase CHEMBL3589 | Kd | 2.52 | 2.52 | 3000000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nischarin | Ki | = | 1258.93 | nM | 5.9 | Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relat... | 10737743 |
| Serine/threonine-protein kinase mTOR | Kd | = | 100000.0 | nM | 4.0 | Dissociation constant when binding to FK506 binding protein (FKBP). | 10411471 |
| Adenosine kinase | Kd | = | 3000000.0 | nM | 2.52 | Inhibition of human adenosine kinase | 11123986 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 4020834 | 10.1021/jm00146a028 | Unchecked | 3 |
| 18851889 | 10.1016/j.ejmech.2008.08.010 | Staphylococcus aureus | 2 |
| 18851889 | 10.1016/j.ejmech.2008.08.010 | Bacillus subtilis | 2 |
| 18851889 | 10.1016/j.ejmech.2008.08.010 | Escherichia coli | 2 |
| 18851889 | 10.1016/j.ejmech.2008.08.010 | Aspergillus niger | 2 |
| 18851889 | 10.1016/j.ejmech.2008.08.010 | Candida albicans | 2 |
| 19243099 | 10.1021/jf803666s | Unchecked | 2 |
| 28197312 | 10.1021/acsmedchemlett.6b00416 | Plasmodium falciparum | 2 |
| 8667357 | 10.1021/jm950589q | No relevant target | 1 |
| 10411471 | 10.1021/jm990073x | Serine/threonine-protein kinase mTOR | 1 |
| 10737743 | 10.1021/jm991124t | Nischarin | 1 |
| 2066976 | 10.1021/jm00111a020 | No relevant target | 1 |
| 11123986 | 10.1021/jm000373a | Adenosine kinase | 1 |
| 9435905 | 10.1021/jm970488n | No relevant target | 1 |
| 10571154 | 10.1016/s0960-894x(99)00509-0 | Nitric oxide synthase, inducible | 1 |
| 28197312 | 10.1021/acsmedchemlett.6b00416 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine