Assay Detail
Binding
CHEMBL679972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against ErmC methylase
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
rRNA adenine N-6-methyltransferase (CHEMBL4251) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis |
Publication
Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 4.48 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127777 | — | — | 1 | 5.00 |
| CHEMBL125085 | — | — | 1 | 4.90 |
| CHEMBL340522 | — | — | 1 | 4.70 |
| CHEMBL125249 | — | — | 1 | 4.43 |
| CHEMBL124572 | — | — | 1 | 4.12 |
| CHEMBL333812 | — | — | 1 | 4.12 |
| CHEMBL331440 | — | — | 1 | 4.12 |
| CHEMBL124519 | — | — | 1 | - |
| CHEMBL330769 | — | — | 1 | - |
| CHEMBL127767 | — | — | 1 | - |
| CHEMBL123502 | — | — | 1 | - |
| CHEMBL126375 | — | — | 1 | - |
| CHEMBL124981 | — | — | 1 | - |
| CHEMBL333773 | — | — | 1 | - |
| CHEMBL126068 | — | — | 1 | - |
| CHEMBL127729 | — | — | 1 | - |
| CHEMBL124520 | — | — | 1 | - |
| CHEMBL331635 | — | — | 1 | - |
| CHEMBL125250 | — | — | 1 | - |
| CHEMBL332852 | — | — | 1 | - |
| CHEMBL338033 | — | — | 1 | - |
| CHEMBL419433 | — | — | 1 | - |
| CHEMBL126964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127777 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL125085 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL340522 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL125249 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL124572 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL333812 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL331440 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL124519 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL330769 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL127767 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL123502 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL126375 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL124981 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL333773 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL126068 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL127729 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL124520 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL331635 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL125250 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL332852 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL338033 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL419433 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL126964 | — | Ki | > | 50000.0 | nM | - |