Compound Detail
CHEMBL124572
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Basic Information
| ChEMBL ID | CHEMBL124572 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UPHUNEXJOGSURX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
340.4
MW (Da)
2.03
ALogP
7
HBA
2
HBD
89.2
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| rRNA adenine N-6-methyltransferase CHEMBL2757 | Ki | 5.22 | 5.22 | 6000.0 | 1 |
| rRNA adenine N-6-methyltransferase CHEMBL4251 | Ki | 4.12 | 4.12 | 75000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| rRNA adenine N-6-methyltransferase | Ki | = | 6000.0 | nM | 5.22 | Inhibitory activity against ErmAM methylase | 10508434 |
| rRNA adenine N-6-methyltransferase | Ki | = | 75000.0 | nM | 4.12 | Inhibitory activity against ErmC methylase | 10508434 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10508434 | 10.1021/jm990293a | rRNA adenine N-6-methyltransferase | 2 |
Data from ChEMBL 36 via Core Engine