Assay Detail
Binding
CHEMBL680018
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Inhibition of epidermal growth factor receptor using enzyme assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.20 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285063 | — | — | 1 | 8.70 |
| CHEMBL94062 | — | — | 1 | 8.70 |
| CHEMBL329856 | — | — | 1 | 8.22 |
| CHEMBL91867 | — | — | 1 | 8.10 |
| CHEMBL91009 | — | — | 1 | 8.05 |
| CHEMBL94061 | — | — | 1 | 7.96 |
| CHEMBL328704 | — | — | 1 | 7.92 |
| CHEMBL93783 | — | — | 1 | 7.85 |
| CHEMBL93386 | — | — | 1 | 7.70 |
| CHEMBL90595 | — | — | 1 | 7.24 |
| CHEMBL93049 | — | — | 1 | 7.23 |
| CHEMBL328245 | — | — | 1 | 7.21 |
| CHEMBL442754 | — | — | 1 | 7.21 |
| CHEMBL327838 | — | — | 1 | 7.19 |
| CHEMBL92356 | — | — | 1 | 7.19 |
| CHEMBL93784 | — | — | 1 | 7.19 |
| CHEMBL94109 | — | — | 1 | 7.17 |
| CHEMBL414220 | — | — | 1 | 7.15 |
| CHEMBL91925 | — | — | 1 | 7.14 |
| CHEMBL316127 | — | — | 1 | 7.13 |
| CHEMBL91811 | — | — | 1 | 7.07 |
| CHEMBL419501 | — | — | 1 | 7.07 |
| CHEMBL92731 | — | — | 1 | 7.05 |
| CHEMBL328977 | — | — | 1 | 7.02 |
| CHEMBL92961 | — | — | 1 | 7.01 |
| CHEMBL94068 | — | — | 1 | 6.97 |
| CHEMBL94066 | — | — | 1 | 6.97 |
| CHEMBL92902 | — | — | 1 | 6.94 |
| CHEMBL2112370 | — | — | 1 | 6.88 |
| CHEMBL2112369 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285063 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL94062 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL329856 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL91867 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL91009 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL94061 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL328704 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL93783 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL93386 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL90595 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL93049 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL328245 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL442754 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL93784 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL92356 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL327838 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL94109 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL414220 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL91925 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL316127 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL419501 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL91811 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL92731 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL328977 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL92961 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL94068 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL94066 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL92902 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2112370 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL2112369 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL93537 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL94123 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL93464 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL91748 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL329642 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL92086 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL93754 | — | IC50 | = | 1124.0 | nM | 5.95 |
| CHEMBL92882 | — | IC50 | = | 1132.0 | nM | 5.95 |