Assay Detail
Functional
CHEMBL680026
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Tested for ability to inhibit autophosphorylation of the Epidermal growth factor receptor in human epidermoid carcinoma cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.00 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294475 | — | — | 1 | 8.51 |
| CHEMBL53426 | — | — | 1 | 8.29 |
| CHEMBL53777 | — | — | 1 | 7.66 |
| CHEMBL299622 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294475 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL53426 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL53777 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL299622 | — | IC50 | = | 30.0 | nM | 7.52 |