Assay Detail
Functional
CHEMBL680027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding modes of 6,7 di-substituted 4-anilinoquinoline-3-carbonitriles to EGFR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.92 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 7.10 |
| CHEMBL116853 | — | — | 1 | 7.05 |
| CHEMBL115187 | — | — | 1 | 6.89 |
| CHEMBL117324 | — | — | 1 | 6.82 |
| CHEMBL113900 | — | — | 1 | 6.60 |
| CHEMBL30973 | — | — | 1 | 6.51 |
| CHEMBL441279 | — | — | 1 | 6.48 |
| CHEMBL327023 | — | — | 1 | 6.26 |
| CHEMBL117326 | — | — | 1 | 6.25 |
| CHEMBL281300 | — | — | 1 | 6.23 |
| CHEMBL323630 | — | — | 1 | 6.19 |
| CHEMBL263788 | — | — | 1 | 6.10 |
| CHEMBL326280 | — | — | 1 | 6.10 |
| CHEMBL324718 | — | — | 1 | 6.09 |
| CHEMBL116525 | — | — | 1 | 6.04 |
| CHEMBL283682 | — | — | 1 | 6.03 |
| CHEMBL115440 | — | — | 1 | 6.03 |
| CHEMBL114593 | — | — | 1 | 6.02 |
| CHEMBL114728 | — | — | 1 | 5.80 |
| CHEMBL326811 | — | — | 1 | 5.79 |
| CHEMBL424252 | — | — | 1 | 5.72 |
| CHEMBL118000 | — | — | 1 | 5.64 |
| CHEMBL114490 | — | — | 1 | 5.63 |
| CHEMBL421047 | — | — | 1 | 5.58 |
| CHEMBL114392 | — | — | 1 | 5.57 |
| CHEMBL116857 | — | — | 1 | 5.54 |
| CHEMBL332497 | — | — | 1 | 5.42 |
| CHEMBL325156 | — | — | 1 | 5.32 |
| CHEMBL113901 | — | — | 1 | 5.28 |
| CHEMBL113985 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607707 | PELITINIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL116853 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL115187 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL117324 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL113900 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL30973 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL441279 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL327023 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL117326 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL281300 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL323630 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL263788 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL326280 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL324718 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL116525 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL283682 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL115440 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL114593 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL114728 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL326811 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL424252 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL118000 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL114490 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL421047 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL114392 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL116857 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL332497 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL325156 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL113901 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL113985 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL113902 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL116012 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL114073 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL113996 | — | IC50 | = | 13600.0 | nM | 4.87 |